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WASHINGTONPOST (Cleve R. Wootson Jr., Praveena Somasundaram, Dan Merica) - Kamala Harris has a 2028 opening — and a 2024 problem

The former Democratic standard bearer retains considerable respect in the party, but there’s an undercurrent of anxiety about her return to the political conversation.

AXIOS (Caitlin Owens) - Missing details keep U.S. plague response on hold

Two big unknowns stand in the way of determining how serious the plague threat in Russia is and whether travel advisories, restrictions at U.S. ports of entry or other precautions are warranted. - We still don't know which pathogen killed a Russian researcher, or how well contained it is. Why it matters: Though public health experts say there's no cause for Americans to panic, the episode serves as a wake-up call emphasizing the nature of global biological threats and the need for pandemic preparedness. State of play: A worker at the Anti-Plague Research Institute of Siberia and the Far East recently died after contracting pneumonia. There are conflicting accounts of how she got sick and whether she was infected with pneumonic plague,…

What recent domestic example of a pneumonic plague case is cited in the report?
The report notes that pneumonic plague cases are rare but have occurred in the U.S. recently. Last year, the CDC launched a pneumonic plague investigation in Arizona after a young adult male died following exposure to two ill cats. During that investigation, officials identified 46 potentially exposed individuals who were administered antibiotics.
Q&A ID 67aec274-c325-484b-9fee-a42e08dbc445
What is the historical context regarding Russia's involvement with plague bacteria and biological weapons?
A 2024 State Department assessment concluded that Russia maintains an offensive biowarfare program, having absorbed and evolved the old Soviet program. Furthermore, the CDC stated that during the 1970s and 1980s, the Soviet Union manufactured large quantities of antibiotic-resistant Y. pestis (the bacteria that causes plague) to be dispersed as a bioweapon. While the specific institute involved in the recent incident was part of an anti-plague network for surveillance, it also developed vaccines and diagnostics for pathogens modified by the military.
Q&A ID 82867b37-8e05-41f2-acc3-e92926b5fc05
What specific actions would the U.S. government take if a formal plague response were required?
According to David Mansdoerfer, a former health official from the first Trump administration, the government's "playbook" includes several steps: the State Department would issue a travel advisory, the government would contact U.S. citizens in the affected area with guidance, and the Centers for Disease Control and Prevention (CDC) would issue a travel health notice. Furthermore, Customs and Border Protection would implement "ill traveler rules," which can include stopping high-risk individuals from boarding flights or flagging health officials at ports of entry.
Q&A ID 7e70741c-bf68-4814-91db-62d995bc6d83
What potential risks have experts identified regarding the specific strain of plague involved in the Russian incident?
Experts have noted that if the worker died from pneumonic plague, there is a possibility it could be a genetically altered version that behaves differently than treatable strains. This concern is linked to the prevalence of "gain-of-function" research and Russia's known history of developing biological weapons. Additionally, there is a concern that the strain might be resistant to standard antibiotics, despite the fact that the U.S. maintains substantial government stockpiles of such medications.
Q&A ID 98c3ee33-679f-4f2f-a1a9-56d148646abe

AXIOS (Marc Caputo) - Scoop: Senate GOP to send $5m to shore up Graham in South Carolina

The main super PAC supporting Republican Senate candidates plans to inject $5 million into the South Carolina campaign as an "insurance policy" to help GOP nominee Darline Graham , a source familiar with the move tells Axios. Why it matters: The GOP's concern that a Senate seat in blood-red South Carolina could be in play shows just how bad the political environment is for Republicans, who face a rash of troubles in states long considered conservative strongholds. - "It's an insurance policy. We're going to be there for Darline," said a Republican briefed on the plans for the Senate Leadership Fund. The shift to spending in conservative South Carolina comes after Senate Republicans announced they no longer were financing ads in…

Who is Darline Graham and how did she receive her appointment to the Senate seat?
Darline Graham is the sister of the late Senator Lindsey Graham. She was appointed to her seat in July at the urging of President Donald Trump, who was a friend of her brother. She won her primary over Rep. Ralph Norman with 52% of the vote following support from Trump.
Q&A ID be3c09ac-4eb1-4195-9d78-1137f408e54f
How does Annie Andrews' campaign funding and strategy differ from previous Democratic challengers in South Carolina?
Unlike Jaime Harrison, who raised $100 million in 2020 and was the state's former Democratic Party chair, Annie Andrews is running as a "mom and a doctor." Her campaign has been largely financed with $3.6 million in contributions bundled by the 314 Action Fund, a political committee that elects Democratic candidates with STEM backgrounds. Because she is not a former party chair, her campaign has been less of a partisan target than previous efforts.
Q&A ID 86c70e84-3c2c-4c16-b5bb-95f31f8392c3
How do the current polls for the South Carolina Senate race between Darline Graham and Annie Andrews compare?
Recent polling has shown a much closer race than expected. A survey from Trafalgar showed a statistical tie with Graham at 43% and Andrews at 42%. InsiderAdvantage also produced a poll showing a 1-point race with Graham at 46% and Andrews at 45%. These figures contrast with earlier September polling from Rasmussen Reports, which showed Graham leading by 5 points.
Q&A ID cabaa83e-57c3-42c5-97c7-137f04d90bf9
What are the specific challenges facing Darline Graham in her bid for the South Carolina Senate seat?
Darline Graham faces several challenges, including being a relatively poor fundraiser compared to her opponent, Annie Andrews, who is outspending and outraising her. Additionally, Graham has been noted for shielding herself from the press and showing a relative lack of mastery of foreign policy during a GOP primary debate. Furthermore, she won her primary over Rep. Ralph Norman with 52% of the vote, leaving some bad feelings with Norman, who briefly suggested a write-in campaign before ultimately endorsing her.
Q&A ID c95a5aed-d396-4f5b-9ab3-78cca8c73bf2

AXIOS (Madison Mills) - Longevity guru Bryan Johnson: "People really want me to die"

LOS ANGELES — Bryan Johnson , the face of the longevity movement who believes he may never die, announced recently that he had an incurable autoimmune disease — and his critics cheered, he told "The Axios Show" in an exclusive interview Monday. - "I mean, I think people really want me to die. Now I get it. It's funny. It's ironic. I push a lot of buttons that people don't like," he said. The big picture: As Johnson himself acknowledged, there's an irony in the founder of the "Don't Die" movement watching people celebrate his diagnosis. But Johnson sees his diagnosis as rocket fuel for his mission to promote longevity, rather than a setback. Catch up quick: Johnson, 49, has autoimmune gastritis (AIG), a chronic condition in which the…

What was Johnson's reaction to the public's reception of his autoimmune disease diagnosis?
Johnson noted that there was "joy all around the world" following his announcement in July. He remarked on the irony of the situation, stating, "I think people really want me to die. Now I get it. It's funny. It's ironic. I push a lot of buttons that people don't like."
Q&A ID 00ecf0b5-5bfd-4cc3-ade1-b9f96e83997c
What concerns have medical experts raised regarding Johnson's approach to intensive health tracking and testing?
Experts warn that intensive health tracking can lead to a "cascade" of follow-up tests due to false positives and incidental findings, which may not be meaningful. These cascades can result in added costs, stress, and potential harm. In contrast, Johnson argues that he appreciates the information because finding issues early makes them more likely to be addressed.
Q&A ID f33d1e8d-e12a-471b-adac-adf226a42779
What is Bryan Johnson's professional background and what companies does he currently operate?
Johnson made his fortune by founding Braintree, which acquired Venmo and was later sold to PayPal for $800 million. He currently runs several businesses related to longevity and technology, including Blueprint, Immortals, the neurotechnology company Kernel, and the venture fund OS Fund.
Q&A ID b1e34193-501c-4e4d-8123-7033426575a3
What is the financial scope and infrastructure of Bryan Johnson's personal health and longevity regimen?
Johnson spends over $2 million a year on personal health and longevity treatments. To support these extreme health interventions, he maintains an entire medical concierge team and has a makeshift doctor's office located inside his home. He also documents these experiments for an online following of roughly 8 million people.
Q&A ID 132a41df-1cde-4820-ade7-9828b6b6dda4

AXIOS (Emily Peck) - Wall Street on track for record profits

Data: NYSE/Intercontinental Exchange via the New York State Comptroller; Chart Emily Peck/Axios; Note: 2026 projected by the comptroller if first-half growth continues at current pace. First-half 2026 profits were $45.9 billion. Profits are for broker-dealer operations of NYSE member firms and are not adjusted for inflation. Wall Street profits are blowing past expectations this year, the New York State Comptroller's office finds in a new report. Why it matters: Profits are on track for an all-time record, a sign of how the AI boom is fueling dealmaking and how volatile markets are helping trading. By the numbers: In the first half of this year, Wall Street firms raked in $45.9 billion — that's 51.3% more than the same period last year,…

How do the projected 2026 profits for Wall Street compare to previous record-setting years?
The projected annual profits, which could exceed $90 billion if current trends hold, are significantly higher than the 2025 record of $65.1 billion. The report also notes that these figures rival the 2009 record even after accounting for inflation.
Q&A ID 60a621f4-690a-4087-9861-fa5b02b196cd
What factors are cited as primary drivers for the record-breaking profits on Wall Street despite potential market headwinds?
The profits are being fueled by the AI boom driving dealmaking, a record year for stocks, the massive SpaceX IPO, and record-breaking M&A activity. Furthermore, war-driven volatility has helped juice trading volume. These factors are driving profits despite headwinds such as the Iran war, higher inflation and interest rates, and the potential for an AI bubble to burst.
Q&A ID 264277bf-b034-4d91-9eb1-1b9626287ff2
What specific market activities contributed to the 68% increase in underwriting fees earned by Wall Street firms during the first half of the year?
The increase in underwriting fees, which involve helping companies sell new stocks and bonds, was driven by a 76.5% increase in global equity issuance. A significant portion of this growth was attributed to the SpaceX initial public offering, which was the biggest ever. Additionally, there was an 11.3% increase in debt issuance, with AI hyperscalers identified as some of the largest borrowers.
Q&A ID e0eab035-91cd-4117-88cd-cc531b2a78da
According to a report from the New York State Comptroller's office, what were the profits for broker-dealer operations of NYSE member firms in the first half of 2026?
In the first half of 2026, Wall Street firms earned $45.9 billion in profits. This figure represents a 51.3% increase compared to the same period in the previous year and already exceeds the $45.3 billion forecast for the entirety of 2026. If this growth pace continues, annual profits could potentially exceed $90 billion.
Q&A ID b2138e3a-83a6-44bc-b50d-c49c57b095c9

AXIOS (Russell Contreras) - Latino group bets on bilingual AI to cut voter confusion before the midterms

A national Latino civic engagement group is turning to an AI app to help voters cut through an increasingly complicated election system — in English or Spanish. Why it matters: Nearly 39 million Hispanics can vote in this year's midterms, and their political loyalties are increasingly up for grabs. - Hispanics have added 5.25 million eligible voters since 2022, more than any other racial or ethnic group, according to Pew Research Center. - The Latino electorate remains highly fluid: About 1 in 7 Latino voters who backed Trump in 2024 now say they want Democrats to control Congress, according to a new NBC News/Telemundo poll . How it works: Mi Familia en Acción launched Nubi last week, a bilingual AI-powered app that answers…

How did Mi Familia en Acción develop and finance the Nubi AI tool?
Nubi is the result of a five-year effort to combine traditional organizing with technology. The organization first launched a basic chatbot about two years ago before developing the current AI version. Mi Familia en Acción financed the development of the app itself, which Sánchez Barba described as a "very big investment," though he did not disclose the specific cost. The organization plans to continue updating the tool as voting rules, court decisions, and government policies change.
Q&A ID bec50ceb-839b-49b5-a842-650735f3649e
Who is the leader of Mi Familia en Acción and what are his statements regarding the nonpartisan nature of the Nubi app?
Héctor Sánchez Barba is the president and CEO of Mi Familia en Acción. He stated that Nubi is nonpartisan and does not recommend specific candidates or causes. He emphasized that the goal of the technology is to provide reliable information in one place so that citizens do not need to be "constitutional lawyers" to understand how to vote. He also noted that while the technology extends civic information into rural or overlooked communities, it is not intended to replace traditional organizing methods like door-knocking.
Q&A ID 31a4d0b1-4e7c-4a9c-9b9f-2ef91f02ba28
Why is the Latino electorate considered a significant demographic for the upcoming midterms according to the provided data?
The Latino electorate is significant because nearly 39 million Hispanics are eligible to vote in the midterms. According to Pew Research Center, Hispanics added 5.25 million eligible voters since 2022, which is more than any other racial or ethnic group. Furthermore, the demographic is projected to account for 16% of eligible voters in 2026, nearly doubling their 9% share in 2006. The data also indicates that the electorate is highly fluid and unpredictable, with 52% of registered Latino voters in 17 competitive House districts reported as undecided or potentially changing their minds as of May 2026.
Q&A ID d674b381-d1be-4c01-a101-5c1f5afcb6e2
What is Nubi and how does it function to assist voters in the United States?
Nubi is a bilingual AI-powered app launched by the national Latino civic engagement group Mi Familia en Acción. It is designed to help voters navigate a complicated election system by answering questions in both English and Spanish regarding voter registration, citizenship, "Know Your Rights" information, and specific voting logistics such as where and when to vote, early voting options, and mail ballots. Unlike general-purpose chatbots, Nubi does not search the open internet; instead, it is fed information from sources selected by the organization, undergoes human review, and includes guardrails to ensure it does not invent responses. It operates in all 50 states and provides information tailored to the local or district level.
Q&A ID bdcf3c21-bd29-48ac-b78c-5df68c9e8927

AXIOS (Andrew Solender) - Scoop: Gun safety groups jump into midterms with $10 million assist for Democrats

Everytown for Gun Safety , a group that advocates for stricter gun laws, is teaming up with House Democrats on a $10 million ad campaign to boost former gun safety advocates now running for Congress, Axios has learned. Why it matters: That's a significant sum at a moment when Democrats are raising alarm bells about being outgunned financially in the midterm elections. - The candidates boosted by the campaign are all former volunteers for another gun safety group, Moms Demand Action. - The candidates include: JoAnna Mendoza of Arizona, Pia Dandiya of Florida, Christina Bohannan and Lindsay James of Iowa, Christina Hines and Rep. Kristen McDonald Rivet of Michigan, and Paige Cognetti of Pennsylvania. "For nearly two years, a MAGA House…

How did the NRCC respond to the news of House Democrats and Everytown for Gun Safety's $10 million ad campaign?
NRCC spokesman Mike Marinella stated that House Democrats have embraced a "radical socialist agenda" involving abolishing prisons, releasing criminals, and defunding the police. He asserted that voters would not believe the Democrats' claims regarding Republicans who have fought to protect communities.
Q&A ID fe6e9ea8-87d4-480e-acef-3f8fd41bf4d6
What is the stated goal of the partnership between Everytown for Gun Safety and House Majority PAC according to Everytown president John Feinblatt?
John Feinblatt stated that the goal is to flip eight seats to put a stop to what he described as a "MAGA House" that has "rubber-stamped the Trump administration as it tore up federal gun safety laws." He noted that there is a Moms Demand Action volunteer on the ballot in every one of these districts.
Q&A ID c144c657-2ad9-4b2e-a739-46a9c0a1eb9b
What themes are the TV and digital ads funded by Everytown for Gun Safety focusing on to support these Democratic candidates?
The ads are focused broadly on "public safety," which includes topics such as gun control, drug trafficking, immigration, crime, and police funding. For example, Christina Bohannan's ad mentions securing the border and hiring more police officers, while Paige Cognetti's ad highlights her work as mayor of Scranton to cut violent crime.
Q&A ID 611759ad-ddfb-429c-a44b-1d614234eca9
Which specific Democratic candidates are being supported by the $10 million Everytown for Gun Safety and House Majority PAC ad campaign?
The candidates being boosted by the campaign are former volunteers for Moms Demand Action and include JoAnna Mendoza of Arizona, Pia Dandiya of Florida, Christina Bohannan and Lindsay James of Iowa, Christina Hines and Rep. Kristen McDonald Rivet of Michigan, and Paige Cognetti of Pennsylvania.
Q&A ID abe796ef-9ba9-4bcc-a7de-ce59d287c620