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AXIOS (Ben Berkowitz) - Murkowski will oppose Blanche, threatening his confirmation

Sen. Lisa Murkowski (R-Alaska) said Friday she will oppose the confirmation of Todd Blanche as attorney general. Why it matters: With two GOP holdouts — Murkowski and Susan Collins (R-Maine) — Blanche faces an increasingly difficult path to being confirmed. What they're saying: "The country needs an Attorney General who will check the worst impulses of this administration. I hope Mr. Blanche is able to achieve that, if confirmed, but I simply do not have confidence that will be the case," Murkowski wrote in a 6 a.m. ET Friday post to X. Zoom out: With Sen. Mitch McConnell (R-Ky.) still absent, Blanche can only afford to lose two Republican votes, assuming McConnell does not return and all Democrats vote against him, Axios' Hans…

Sen. Lisa Murkowski (R-Alaska) said Friday she will oppose the confirmation of Todd Blanche as attorney general. Why it matters: With two GOP holdouts — Murkowski and Susan Collins (R-Maine) — Blanche faces an increasingly difficult path to being confirmed. What they're saying: "The country needs an Attorney General who will check the worst impulses of this administration. I hope Mr. Blanche is able to achieve that, if confirmed, but I simply do not have confidence that will be the case," Murkowski wrote in a 6 a.m. ET Friday post to X. Zoom out: With Sen. Mitch McConnell (R-Ky.) still absent, Blanche can only afford to lose two Republican votes, assuming McConnell does not return and all Democrats vote against him, Axios' Hans…Open

NPR (Mara Gordon) - Everyone's talking about hormone therapy for menopause. Should I be on it?

For years doctors advised women against hormone therapy for women in the menopausal transition. Now everyone's talking about how great it is. Is it really a wonder drug that women should all be on?

For years doctors advised women against hormone therapy for women in the menopausal transition. Now everyone's talking about how great it is. Is it really a wonder drug that women should all be on?Open

NPR (Bobby Allyn) - Kalshi and Polymarket bets on clinical trials criticized as 'ghastly'

Researchers warn betting on clinical trials could incentivize insider trading and interfere with drug development. But Kalshi and Polymarket say they provide valuable information to patients.

Researchers warn betting on clinical trials could incentivize insider trading and interfere with drug development. But Kalshi and Polymarket say they provide valuable information to patients.Open

NYTIMES (David Ovalle and Laura N. Pérez Sánchez) - Drought and Aging Pipes Plunge Puerto Rico Into Another Water Crisis

The disaster has put yet another spotlight on the government’s inability to provide basic services, deepening frustration among residents already plagued by regular power outages.