Some protesters condemned the strikes and killing of Iran's supreme leader, calling for an end to military action in the Middle East, while others cheered in support of the U.S. military action.
As Iran retaliates with strikes of its own, the attacks now risk disrupting a major oil supply that could trickle down to what Americans pay at the pump.
The fighting in the region is leaving thousands of Americans there uncertain about their situation. ABC News' Chief International Correspondent James Longman reports from Turkey.
The Middle East was rocked by another night of air attacks pitting the U.S. and Israel against Iran. ABC News' Chief Foreign Correspondent Ian Pannell reports from Tel Aviv, Israel.
Tina Ghazimorad, political editor and head of news of Monato TV, a London-based Iranian TV channel, reacts to the killing of Iran's supreme leader, Ayatollah Ali Khamenei. "People are extremely happy. Imagine someone who is responsible for the killings and mass murders of people," she said on "Morning in America with Hena Doba." Start your day with "Morning in America," NewsNation's live three-hour national weekend morning newscast hosted by Hena Doba. Saturday and Sunday starting at 7a/6C. #MorningInAmerica NewsNation is your source for fact-based, unbiased news for all Americans.
American and Israeli forces launched a preemptive strike on Iran in the early hours of Saturday, killing Ayatollah Ali Khomeini and much of the senior military leadership.