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STONEZONE (Roger Stone) - Big Pharma Will Never Help the People

Promising, inexpensive generic drugs may never receive large-scale testing as anti-aging treatments—not because the science is weak, but because the pharmaceutical regulatory system rewards patentable products over affordable public-health solutions. Metformin and rapamycin have shown potential in animal research to influence aging-related biological processes. Yet definitive human trials remain limited. The central obstacle is financial: […] The post Big Pharma Will Never Help the People appeared first on StoneZone .

Promising, inexpensive generic drugs may never receive large-scale testing as anti-aging treatments—not because the science is weak, but because the pharmaceutical regulatory system rewards patentable products over affordable public-health solutions. Metformin and rapamycin have shown potential in animal research to influence aging-related biological processes. Yet definitive human trials remain limited. The central obstacle is financial: rigorous Phase 3 trials can cost hundreds of millions of dollars, while manufacturers have little incentive to fund studies of off-patent drugs that competitors could immediately sell at low prices. That market failure becomes a regulatory failure when government agencies rely primarily on…Open

What is the stated goal of RFK Jr. regarding the healthcare system according to the article?
RFK Jr. is trying to return the country back to a system where the vulnerable are not harmed for Big Pharma's profit models.
Q&A ID 1ea03468-2555-4f64-badb-89a0f124afef
What are some independent efforts currently attempting to fill the research gap for aging-related treatments?
Independent projects such as the proposed TAME metformin trial and a federally funded rapamycin study are attempting to fill the gap left by the lack of industry-sponsored research for generics.
Q&A ID 5b7c9620-5858-42c3-afa9-b7547e3742ff
How has the funding structure of the FDA impacted its regulatory role according to a Government Accountability Office report?
A Government Accountability Office report found that industry-paid user fees had grown to cover 61.5% of FDA drug-review costs by fiscal year 2010. Current law continues to authorize these payments in exchange for agency performance commitments, which some describe as structural capture where public rules and research priorities align with the business models of the industry being regulated.
Q&A ID cdd80c85-fb63-4817-b576-85c73796af4e
Which specific drugs have shown potential in animal research to influence biological processes related to aging?
Metformin and rapamycin have both shown potential in animal research to influence aging-related biological processes, though definitive human trials for them remain limited.
Q&A ID 9a6da07b-ee11-4859-b7f8-6674c29576ad
Why might promising, inexpensive generic drugs fail to receive large-scale testing for use as anti-aging treatments?
The failure is not due to weak science, but because the pharmaceutical regulatory system rewards patentable products over affordable public-health solutions. Manufacturers lack the financial incentive to fund rigorous Phase 3 trials, which can cost hundreds of millions of dollars, for off-patent drugs that competitors could immediately sell at low prices.
Q&A ID 3ee9e232-51b1-4239-8812-d428a3331705

STONEZONE (Roger Stone) - Taxing Your Way to Socialism

The dream of Islamic socialist Zoran Mamdani to sell the American electorate the supposed miracles of socialism has come to an end. Tax revenues are collapsing in New York. With that, the dream of Islamic socialist Zoran Mamdani to sell the American electorate the supposed miracles of socialism has come to an end. Only fools […] The post Taxing Your Way to Socialism appeared first on StoneZone .

The dream of Islamic socialist Zoran Mamdani to sell the American electorate the supposed miracles of socialism has come to an end. Tax revenues are collapsing in New York. With that, the dream of Islamic socialist Zoran Mamdani to sell the American electorate the supposed miracles of socialism has come to an end. Only fools refuse to learn: Those who bite the hand that feeds them will eventually starve. Socialism always ends in the same misery. Quite apart from the fact that it represents a vulgar and contempt for human dignity ideology, its fiscal parasitism is impossible to overlook. Put simply: socialism functions only as long as it can feed on the economic substance of the middle class and the wealthy. Only by disregarding…Open

YOUTUBE (NewsNation) - How recent conflicts have utilized “directed energy weapons”

Maj. Glenn Ignazio, a retired Air Force special operations commander and defense technology expert, discusses how recent conflicts, including the Russia-Ukraine war and the U.S.-Iran conflict, have accelerated the use of directed energy weapons on the battlefield. Watch this full episode of "The Truth of the Matter" on Spotify or NewsNation's YouTube channel

NEWSNATIONNOW (Sarah Davis and The Hill) - Mamdani floats arresting Netanyahu if he visits NYC for UN General Assembly

The mayor made these comments an interview with Lulu Garcia-Navarro on Saturday episode of The New York Times’ “The Interview" podcast.

THEAMERICANCONSERVATIVE (Luke Nicastro) - BREAKING: Third American Service Member Killed in Iran War This Weekend

State of the Union: The Pentagon announced the death of another U.S. soldier in Iraq and is working to identify human remains in Jordan. The post BREAKING: Third American Service Member Killed in Iran War This Weekend appeared first on The American Conservative .

U.S. Central Command (CENTCOM) announced Sunday that a third service member had been killed in action this weekend. The service member, who has not been named, was killed in northern Iraq during what CENTCOM described as a “controlled detonation of unexploded ordnance from a downed Iranian one-way attack drone.” Another service member was injured in the incident and is receiving medical care. CENTCOM also confirmed that it had recovered unidentified human remains from Jordan, where a separate Iranian attack Saturday resulted in two confirmed U.S. deaths and one service member reported missing in action. Efforts to identify the remains are “ongoing,” according to the Pentagon. The three confirmed fatalities this weekend bring the…Open

YOUTUBE (The Hill) - Daylight saving: The fight to stop falling back | The Hill Sunday

Are you sick of changing your clocks twice a year? Well, one party wants to make one last change. The Republican House passed a bill to lock the clock and keep DST year-round, and President Trump wants the Senate to do the same. #daylightsaving #politics #senate #house #democrats #republicans

AMERICANALMANAC (Alan Benson) - Jennifer Finch, L7 bassist and punk fixture, dead at 59 after brain cancer battle

Jennifer Finch, the bassist and vocalist who helped define the sound of L7 across three decades of punk and alternative rock, has died at the age of 59 following a fight with an aggressive form of brain cancer. Her family announced her death on her Instagram page, calling her impact on music "seismic." Finch joined […] The post Jennifer Finch, L7 bassist and punk fixture, dead at 59 after brain cancer battle appeared first on American Almanac .

Jennifer Finch, the bassist and vocalist who helped define the sound of L7 across three decades of punk and alternative rock, has died at the age of 59 following a fight with an aggressive form of brain cancer. Her family announced her death on her Instagram page, calling her impact on music "seismic." Finch joined L7 in 1986 and contributed bass and vocals on five of the band's seven albums. She was also a photographer, visual artist, and member of several other projects, including the Shocker, Sugar Babylon, and Other Star People, the last of which placed music on television shows including Buffy the Vampire Slayer and Degrassi: The Next Generation. Her death, reported by Entertainment Weekly , came roughly one week after L7 publicly…Open

AMERICANALMANAC (Sadie Smith) - Samantha Morton's real-life magic act finds its stage in Nolan's 'The Odyssey'

Before she played a sorceress on screen, Samantha Morton was pulling off illusions for real. The 49-year-old British actress, who portrays the enchantress Circe in Christopher Nolan's new epic The Odyssey, spent years as a teenager working as a magician's assistant, a chapter of her life that, by her own telling, fed directly into one […] The post Samantha Morton's real-life magic act finds its stage in Nolan's 'The Odyssey' appeared first on American Almanac .

Before she played a sorceress on screen, Samantha Morton was pulling off illusions for real. The 49-year-old British actress, who portrays the enchantress Circe in Christopher Nolan's new epic The Odyssey, spent years as a teenager working as a magician's assistant, a chapter of her life that, by her own telling, fed directly into one of the summer's most talked-about performances. In an interview with Entertainment Weekly , Morton described how a fellow member of the Central Junior Television Workshop in Nottingham, a drama group for working-class youths, was also part of the Magic Circle, Britain's storied organization for professional magicians. He asked Morton to be his assistant, and she kept at it until she was 16. The role was more…Open